MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients.

doi:10.1016/j.meegid.2019.104093

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Article

MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2020

Saranathan Rajagopalan, Sathyamurthi Pattabiraman, Thiruvengadam Kannan, Murugesan Selvachithiram, Shivakumar Shri Vijay Bala Yogendra, Gomathi Narayanan Sivaramakrishnan, Kavitha Dhanasekaran, Paradkar Mandar, Puvaneshwari Rohini, Kannan Muthuramalingam, Madheswaran Annamalai, Pradhan Neeta, Kulkarni Vandana, Gupte Akshay N, Gupte Nikhil, Mave Vidya, Bollinger Robert C, Gupta Amita, Padmapriyadarsini Chandrasekaran, Hanna Luke Elizabeth

Abstract excerpt

OBJECTIVE: Though several genetic variants have been recognized to be associated with susceptibility to Tuberculosis (TB) infection and disease, a recent observation on the association of TIRAP C975T (S180L) variants with TB disease severity in mice model prompted us to assess their relevance in humans. In addition, TIRAP variants have also been reported to be associated with varied circulating Interferon-gamma...

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PMID: 31678649
DOI: 10.1016/j.meegid.2019.104093

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