Article
Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.
International journal of molecular medicine - 1 Jun 2011
An Yang, Ohnishi Hidenori, Matsui Eiko, Funato Michinori, Kato Zenichiro, Teramoto Takahide, Kaneko Hideo, Kimura Takeshi, Kubota Kazuo, Kasahara Kimiko, Kondo Naomi
Abstract excerpt
Toll-like receptors (TLRs) are important pathogen-associated molecular pattern recognition receptors involved in initiating immune responses. The adaptor protein MyD88 adaptor-like (Mal), involved in signaling downstream of TLRs, plays a crucial role in mediating NF-κB activation. The association of Mal polymorphisms with allergic diseases has not previously been defined. The objective of this study was to detect...
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