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Article

Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

16 Feb 2016

Abstract excerpt

BACKGROUND: Aberrant Wnt signaling activation occurs commonly in colorectal carcinogenesis, leading to upregulation of many target genes. APC (adenomatous polyposis coli) is an important component of the β-catenin destruction complex, which regulates Wnt signaling, and is often mutated in colorectal cancer (CRC). In addition to mutational events, epigenetic changes arise frequently in CRC, specifically, promoter...

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Share to Epigenetics and DNA Methylation
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 26884349
DOI: 10.1186/s12885-016-2149-9

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