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Article

The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.

Gastroenterology - 1 Jan 2007

Goel Ajay, Nagasaka Takeshi, Arnold Christian N, Inoue Toru, Hamilton Cody, Niedzwiecki Donna, Compton Carolyn, Mayer Robert J, Goldberg Richard, Bertagnolli Monica M, Boland C Richard

Abstract excerpt

BACKGROUND & AIMS: The CpG island methylator phenotype (CIMP) is one of the mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the cause of high-frequency microsatellite instability (MSI-H) sporadic CRCs, its role in microsatellite stable (MSS) tumors is debated. The majority of MSS CRCs demonstrate chromosomal instability (CIN) with frequent loss of heterozygosity (LOH) at key...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17087942
DOI: 10.1053/j.gastro.2006.09.018

Genes

BRAF
APC
HIC1
PTEN
RUNX3
TIMP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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