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Article

Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2009

Kumar Krishan, Brim Hassan, Giardiello Francis, Smoot Duane T, Nouraie Mehdi, Lee Edward L, Ashktorab Hassan

Abstract excerpt

PURPOSE: Colorectal cancer develops through genetic, epigenetic, and environmental events that result in uncontrolled cell proliferation. Colorectal cancer incidence and mortality is higher in African Americans (AA) than in the general population. Here, we carried out a molecular analysis of sporadic colorectal cancer tumors from AAs to investigate possible explanations for the observed disparities. EXPERIMENTAL...

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Source

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Identifiers

PMID: 19190129
DOI: 10.1158/1078-0432.CCR-08-1029
PMCID: PMC2713502

Genes

BRAF
KRAS
MLH1
APC
APC2
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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