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Article

Promoter methylation of Wnt antagonistsDKK1andSFRP1is associated with opposing tumor subtypes in two large populations of colorectal cancer patients

8 Feb 2011

Abstract excerpt

Aberrant activation of canonical Wnt signaling is a hallmark event in colorectal carcinogenesis. The Dickkopf-1 (DKK1) and Secreted Frizzled Related Protein 1 (SFRP1) genes encode extracellular inhibitors of Wnt signaling that are frequently silenced by promoter hypermethylation in colorectal cancer (CRC). These methylation events have been identified as prognostic markers of patient outcome and tumor subtype in...

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Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 21304055
DOI: 10.1093/carcin/bgr020

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