Article
Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients.
British journal of cancer - 7 Jun 2011
Rawson J B, Mrkonjic M, Daftary D, Dicks E, Buchanan D D, Younghusband H B, Parfrey P S, Young J P, Pollett A, Green R C, Gallinger S, McLaughlin J R, Knight J A, Bapat B
Abstract excerpt
BACKGROUND: In colorectal cancer (CRC), tumour microsatellite instability (MSI) status and CpG island methylator phenotype (CIMP) status are indicators of patient outcome, but the molecular events that give rise to these outcomes remain largely unknown. Wnt5a is a critical regulator of non-canonical Wnt activity and promoter hypermethylation of this gene has emerging prognostic roles in CRC; however the frequency...
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