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Colorectal Cancer With Mutation in <i>BRAF</i>, <i>KRAS</i>, and Wild-Type With Respect to Both Oncogenes Showing Different Patterns of DNA Methylation

12 Nov 2004

Abstract excerpt

PURPOSE: BRAF mutations are common in sporadic colorectal cancers (CRCs) with a DNA mismatch repair (MMR) deficiency that results from promoter methylation of hMLH1, whereas KRAS mutations are common in MMR proficient CRCs associated with promoter methylation of MGMT. The aim of this study was to further investigate the link between genetic alterations in the RAS/RAF/ERK pathway and an underlying epigenetic...

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PMID: 15542810
DOI: 10.1200/jco.2004.02.154

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