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Article

Bethesda Guidelines: Relation to Microsatellite Instability and <i>MLH1</i> Promoter Methylation in Patients with Colorectal Cancer

16 Oct 2001

Abstract excerpt

BACKGROUND: Microsatellite instability is a hallmark of mismatch repair deficiency in hereditary nonpolyposis colorectal cancer and results from mutations in the mismatch repair genes MLH1 or MSH2 or from gene inactivation associated with DNA methylation. The Bethesda guidelines were established to identify patients with colorectal cancer who should be tested for microsatellite instability. OBJECTIVE: To assess...

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PMID: 11601928
DOI: 10.7326/0003-4819-135-8_part_1-200110160-00007

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