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Article

Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.

Oncotarget - 22 Mar 2016

Messina Monica, Chiaretti Sabina, Wang Jiguang, Fedullo Anna Lucia, Peragine Nadia, Gianfelici Valentina, Piciocchi Alfonso, Brugnoletti Fulvia, Di Giacomo Filomena, Pauselli Simona, Holmes Antony B, Puzzolo Maria Cristina, Ceglie Giulia, Apicella Valerio, Mancini Marco, Te Kronnie Geertruy, Testi Anna Maria, Vitale Antonella, Vignetti Marco, Guarini Anna, Rabadan Raul, Foà Robin

Abstract excerpt

To shed light into the molecular bases of B-lineage acute lymphoblastic leukemia lacking known fusion transcripts, i.e. BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL rearrangements (B-NEG ALL) and the differences between children, adolescents/young adults (AYA) and adults, we analyzed 168 B-NEG ALLs by genome-wide technologies. This approach showed that B-NEG cases carry 10.5 mutations and 9.1 copy-number...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26883104
DOI: 10.18632/oncotarget.7356
PMCID: PMC4924686

Genes

FLT3
ABL1
BCR
ETV6
KRAS
NRAS
PBX1
RUNX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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