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Article

New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia

31 Mar 2016

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is a heterogeneous disease at the genetic level. Chromosomal abnormalities are used as diagnostic, prognostic and predictive biomarkers to provide subtype, outcome and drug response information. t(12;21)/ETV6-RUNX1 and high hyper-diploidy are good-risk prognostic biomarkers whereas KMT2A(MLL) translocations, t(17;19)/TCF3-HLF, haploidy or low hypodiploidy are high-risk...

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PMID: 27033238
DOI: 10.3324/haematol.2015.141101

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