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Article

Clinical significance of recurrent copy number aberrations in B-lineage acute lymphoblastic leukaemia without recurrent fusion genes across age cohorts.

British journal of haematology - 1 Aug 2017

Messina Monica, Chiaretti Sabina, Fedullo Anna Lucia, Piciocchi Alfonso, Puzzolo Maria Cristina, Lauretti Alessia, Gianfelici Valentina, Apicella Valerio, Fazi Paola, Te Kronnie Geertruy, Testi Anna Maria, Vitale Antonella, Guarini Anna, Foà Robin

Abstract excerpt

Copy number aberrations (CNAs) represent cooperating events in B-lineage acute lymphoblastic leukaemia (B-ALL); however, their clinical relevance across different age cohorts is unclear. We analysed the recurrent CNAs in 157 age-stratified B-ALL negative cases for recurrent rearrangements (B-NEG ALL), and their association with patients' clinico-biological features. We found that: (i) CDKN2A/RB1-deleted and...

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Identifiers

PMID: 28439887
DOI: 10.1111/bjh.14721

Genes

EBF1
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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