Article
Clinical screening for Ph-like ALL and the developing role of TKIs.
Hematology. American Society of Hematology. Education Program - 9 Dec 2022
Tran Thai Hoa, Tasian Sarah K
Abstract excerpt
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a common subtype of B-lineage acute lymphoblastic leukemia (B-ALL) with increasing frequency across the age spectrum. Characterized by a kinase-activated gene expression profile and driven by a variety of genetic alterations involving cytokine receptors and kinases, Ph-like ALL is associated with high rates of residual disease and relapse...
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