Article
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
The New England journal of medicine - 11 Sept 2014
Roberts Kathryn G, Li Yongjin, Payne-Turner Debbie, Harvey Richard C, Yang Yung-Li, Pei Deqing, McCastlain Kelly, Ding Li, Lu Charles, Song Guangchun, Ma Jing, Becksfort Jared, Rusch Michael, Chen Shann-Ching, Easton John, Cheng Jinjun, Boggs Kristy, Santiago-Morales Natalia, Iacobucci Ilaria, Fulton Robert S, Wen Ji, Valentine Marcus, Cheng Cheng, Paugh Steven W, Devidas Meenakshi, Chen I-Ming, Reshmi Shalini, Smith Amy, Hedlund Erin, Gupta Pankaj, Nagahawatte Panduka, Wu Gang, Chen Xiang, Yergeau Donald, Vadodaria Bhavin, Mulder Heather, Winick Naomi J, Larsen Eric C, Carroll William L, Heerema Nyla A, Carroll Andrew J, Grayson Guy, Tasian Sarah K, Moore Andrew S, Keller Frank, Frei-Jones Melissa, Whitlock James A, Raetz Elizabeth A, White Deborah L, Hughes Timothy P, Guidry Auvil Jaime M, Smith Malcolm A, Marcucci Guido, Bloomfield Clara D, Mrózek Krzysztof, Kohlschmidt Jessica, Stock Wendy, Kornblau Steven M, Konopleva Marina, Paietta Elisabeth, Pui Ching-Hon, Jeha Sima, Relling Mary V, Evans William E, Gerhard Daniela S, Gastier-Foster Julie M, Mardis Elaine, Wilson Richard K, Loh Mignon L, Downing James R, Hunger Stephen P, Willman Cheryl L, Zhang Jinghui, Mullighan Charles G
Abstract excerpt
BACKGROUND: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults....
Read the complete abstract on PubMed