Article
The RAS-signaling-pathway-mutation-related prognosis in B-cell acute lymphoblastic leukemia: A report from South China children's leukemia group.
Hematological oncology - 1 May 2024
Li Xinyu, Lin Shaofen, Liao Ning, Mai Huirong, Long Xingjiang, Liu Lili, Wu Beiyan, Chen Qiwen, Kong Qian, Kong Xianling, Liu Lixia, Qin Jiayue, Fang Jianpei, Zhou Dunhua
Abstract excerpt
The next-generation sequencing technologies application discovers novel genetic alterations frequently in pediatric acute lymphoblastic leukemia (ALL). RAS signaling pathway mutations at the time of relapse ALL frequently appear as small subclones at the time of onset, which are considered as the drivers in ALL relapse. Whether subclones alterations in the RAS signaling pathway should be considered for risk group...
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