Article
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Blood - 22 Jun 2017
Reshmi Shalini C, Harvey Richard C, Roberts Kathryn G, Stonerock Eileen, Smith Amy, Jenkins Heather, Chen I-Ming, Valentine Marc, Liu Yu, Li Yongjin, Shao Ying, Easton John, Payne-Turner Debbie, Gu Zhaohui, Tran Thai Hoa, Nguyen Jonathan V, Devidas Meenakshi, Dai Yunfeng, Heerema Nyla A, Carroll Andrew J, Raetz Elizabeth A, Borowitz Michael J, Wood Brent L, Angiolillo Anne L, Burke Michael J, Salzer Wanda L, Zweidler-McKay Patrick A, Rabin Karen R, Carroll William L, Zhang Jinghui, Loh Mignon L, Mullighan Charles G, Willman Cheryl L, Gastier-Foster Julie M, Hunger Stephen P
Abstract excerpt
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype characterized by genomic alterations that activate cytokine receptor and kinase signaling. We examined the frequency and spectrum of targetable genetic lesions in a retrospective cohort of 1389 consecutively diagnosed patients with childhood B-lineage ALL with high-risk clinical features and/or elevated minimal...
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