Article
Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations.
American journal of hematology - 1 Nov 2018
Mi Xiaoli, Griffin Gabriel, Lee Winston, Patel Sanjay, Ohgami Robert, Ok Chi Young, Wang Sa, Geyer Julia T, Xiao Wenbin, Roshal Mikhail, Garcia Jacqueline S, Silverman Lewis B, Sallan Stephen E, Aster Jon C, Harris Marian H, Weinberg Olga K
Abstract excerpt
The B/T subtype of mixed phenotype acute leukemia (B/T MPAL) is defined by co-expression of antigens of both B- and T-cell lineages on leukemic blasts. Although it has been suggested that multilineage antigen expression portends poor response to chemotherapy, the clinical characteristics and driver mutations that underlie the pathogenesis of this rare subtype of acute leukemia are scarcely known. We identified...
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