Article
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Blood - 15 Sept 2011
Zhang Jinghui, Mullighan Charles G, Harvey Richard C, Wu Gang, Chen Xiang, Edmonson Michael, Buetow Kenneth H, Carroll William L, Chen I-Ming, Devidas Meenakshi, Gerhard Daniela S, Loh Mignon L, Reaman Gregory H, Relling Mary V, Camitta Bruce M, Bowman W Paul, Smith Malcolm A, Willman Cheryl L, Downing James R, Hunger Stephen P
Abstract excerpt
We sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias, the largest pediatric cancer genome sequencing effort reported to date. Integrated analysis of 179 validated somatic sequence mutations with genome-wide copy number alterations and gene expression profiles revealed a high frequency of recurrent somatic alterations in key signaling pathways, including B-cell...
Topics
- Child
- Child, Preschool
- Cohort Studies
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genes, ras
- Humans
- Infant