Article
Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid.
Scientific reports - 15 Feb 2016
Gao Luna, Yang Pu, Qin Peizhong, Lu Yungang, Li Xinxin, Tian Quan, Li Yang, Xie Chang, Tian Jin-bin, Zhang Chengwei, Tian Changlin, Zhu Michael X, Yao Jing
Abstract excerpt
Temperature-sensitive TRP channels are important for responses to pain and inflammation, to both of which tissue acidosis is a major contributing factor. However, except for TRPV1, acid-sensing by other ThermoTRP channels remains mysterious. We show here that unique among TRPV1-3 channels, TRPV3 is directly activated by protons from cytoplasmic side. This effect is very weak and involves key cytoplasmic residues...
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