Article
Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
eLife - 18 May 2023
Gochman Aaron, Tan Xiao-Feng, Bae Chanhyung, Chen Helen, Swartz Kenton J, Jara-Oseguera Andres
Abstract excerpt
The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2. Using the patch-clamp technique, we discover that CBD can sensitize current responses of the rat TRPV2 channel to the synthetic agonist 2-aminoethoxydiphenyl borate (2-APB) by over two orders of...
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