Article
Tunable calcium current through TRPV1 receptor channels.
The Journal of biological chemistry - 14 Nov 2008
Samways Damien S K, Khakh Baljit S, Egan Terrance M
Abstract excerpt
TRPV1 receptors are polymodal cation channels that open in response to diverse stimuli including noxious heat, capsaicin, and protons. Because Ca2+ is vital for TRPV1 signaling, we sought to precisely measure its contribution to TRPV1 responses and discovered that the Ca2+ current was tuned by the mode of activation. Using patch clamp photometry, we found that the fraction of the total current carried by Ca2+...
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