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Article

Irritant-evoked activation and calcium modulation of the TRPA1 receptor.

Nature - 1 Sept 2020

Zhao Jianhua, Lin King John V, Paulsen Candice E, Cheng Yifan, Julius David

Abstract excerpt

The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including small volatile environmental toxicants and endogenous algogenic lipids1. TRPA1 is also a 'receptor-operated' channel whose activation downstream of metabotropic receptors elicits inflammatory pain or itch,...

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Source

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Identifiers

PMID: 32641835
DOI: 10.1038/s41586-020-2480-9
PMCID: PMC7483980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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