Article

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

2023-01-27

Abstract excerpt

The cation-permeable TRPV2 channel is essential for cardiac and immune cells. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2. Using the patch-clamp technique we discover that CBD can sensitize current responses of the rat TRPV2 channel to the synthetic agonist 2-aminoethoxydiphenyl borate (2- APB) by over two orders of magnitude, without...

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Identifiers and source

Literature Corpus work: ba1cdfa5-967a-58ba-8384-5d0ac8a32402
DOI: 10.1101/2023.01.27.525817

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