Article
Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
Neuroscience - 6 Aug 2015
Zhuo R-G, Liu X-Y, Zhang S-Z, Wei X-L, Zheng J-Q, Xu J-P, Ma X-Y
Abstract excerpt
2-Aminoethoxydiphenyl borate (2-APB) has been recently identified as a common agonist of TWIK-related K(+) channel (TREK)/TRAAK channels, a subfamily of two-pore domain K(+) (K2P) channels. TREK-2 displays much higher sensitivity to 2-APB compared with TREK-1, despite that these two channels share the highest homology among K2P members. However, the structural basis for their difference in response to 2-APB still...
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