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Article

Genetic Variation in NFKBIE Is Associated With Increased Risk of Pneumococcal Meningitis in Children.

EBioMedicine - 1 Jan 2016

Lundbo Lene F, Harboe Zitta Barrella, Clausen Louise N, Hollegaard Mads V, Sørensen Henrik T, Hougaard David M, Konradsen Helle B, Nørgaard Mette, Benfield Thomas

Abstract excerpt

BACKGROUND: Streptococcus pneumoniae and Neisseria meningitidis are frequent pathogens in life-threatening infections. Genetic variation in the immune system may predispose to these infections. Nuclear factor-κB is a key component of the TLR-pathway, controlled by inhibitors, encoded by the genes NFKBIA, NFKBIE and NFKBIZ. We aimed to replicate previous findings of genetic variation associated with invasive...

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Identifiers

PMID: 26870821
DOI: 10.1016/j.ebiom.2015.11.048
PMCID: PMC4739413

Genes

NFKBIE
NFKBIA
NFKBIZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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