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Article

Single nucleotide polymorphisms in TLR9 are highly associated with susceptibility to bacterial meningitis in children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Feb 2011

Sanders Marieke S, van Well Gijs Th J, Ouburg Sander, Lundberg Patric S J, van Furth A Marceline, Morré Servaas A

Abstract excerpt

BACKGROUND: Bacterial meningitis (BM) is a severe infection mainly caused by Streptococcus pneumoniae and Neisseria meningitidis (NM). However, genetically determined susceptibility to develop severe infections by these microorganisms is variable between individuals. Toll-like receptor 9 (TLR9) recognizes bacterial DNA leading to intracellular inflammatory signaling. Single nucleotide polymorphisms (SNPs) within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21258099
DOI: 10.1093/cid/ciq155

Genes

TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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