Article
IkappaB genetic polymorphisms and invasive pneumococcal disease.
American journal of respiratory and critical care medicine - 15 Jul 2007
Chapman Stephen J, Khor Chiea C, Vannberg Fredrik O, Frodsham Angela, Walley Andrew, Maskell Nicholas A, Davies Christopher W H, Segal Shelley, Moore Catrin E, Gillespie Stephen H, Denny Paul, Day Nicholas P, Crook Derrick W, Davies Robert J O, Hill Adrian V S
Abstract excerpt
RATIONALE: Increasing evidence supports a key role for the transcription factor nuclear factor (NF)-kappaB in the host response to pneumococcal infection. Control of NF-kappaB activity is achieved through interactions with the IkappaB family of inhibitors, encoded by the genes NFKBIA, NFKBIB, and NFKBIE. Rare NFKBIA mutations cause immunodeficiency with severe bacterial infection, raising the possibility that...
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