Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome.

EBioMedicine - 1 Aug 2016

Ferwerda Bart, Valls Serón Mercedes, Jongejan Aldo, Zwinderman Aeilko H, Geldhoff Madelijn, van der Ende Arie, Baas Frank, Brouwer Matthijs C, van de Beek Diederik

Abstract excerpt

Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Early recognition of the pathogen and subsequent innate immune response play a vital role in disease susceptibility and outcome. Genetic variations in innate immune genes can alter the immune response and influence susceptibility and outcome of meningitis disease. Here we conducted a sequencing study of coding regions from 46...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Immunity, Innate

Share to Patient Outcome Assessment

Share to Prognosis

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 27432718
DOI: 10.1016/j.ebiom.2016.07.011
PMCID: PMC5006661

Genes

IRAK4
CARD8
CXCL1
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome.PMID 27432718Read ↗

Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.Semantic proximity Read ↗

Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis.Semantic proximity Read ↗

Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort.Semantic proximity Read ↗

Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data.Semantic proximity Read ↗

How many single-nucleotide polymorphisms (SNPs) must be tested in order to prove susceptibility to bacterial meningitis in children? Analysis of 11 SNPs in seven genes involved in the immune response and their effect on the susceptibility to bacterial meningitis in children.Semantic proximity Read ↗

Association of Polymorphisms in IRAK1, IRAK4 and MyD88, and Severe Invasive Pneumococcal Disease.Semantic proximity Read ↗

Genetic variations of toll-like receptors: Impact on susceptibility, severity and prognosis of bacterial meningitis.Semantic proximity Read ↗

Genetic Variation in NFKBIE Is Associated With Increased Risk of Pneumococcal Meningitis in Children.Semantic proximity Read ↗

Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members.Semantic proximity Read ↗

Genetic susceptibility to invasive pneumococcal disease.Semantic proximity Read ↗

Exome Array Analysis of Susceptibility to Pneumococcal Meningitis.Semantic proximity Read ↗

Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.