Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene Polymorphisms of TLR2 Subfamily and Bacterial Meningitis in Angolan Children.

Genes - 25 Feb 2026

Teräsjärvi Johanna, Tenhu Elina, Cruzeiro Manuel Leite, Savonius Okko, Rugemalira Emilie, He Qiushui, Pelkonen Tuula

Abstract excerpt

BACKGROUND/OBJECTIVES: Bacterial meningitis is a severe disease with a fatality rate of 5-50%. It is mainly caused by Streptococcus pneumoniae or Neisseria meningitidis, which can also cause simultaneous infections outside the central nervous system. Toll-like receptors (TLRs) have an important role in the innate immune system. The TLR2 subfamily comprises the four highly homologous members TLR1, TLR2, TLR6, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Meningitis, Bacterial
Share to Angola
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Infant

Share to Polymorphism, Single Nucleotide

Share to Streptococcus pneumoniae

Share to Toll-Like Receptor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 41898794
DOI: 10.3390/genes17030260
PMCID: PMC13025349

Genes

TLR2
TLR10
TLR1
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene Polymorphisms of TLR2 Subfamily and Bacterial Meningitis in Angolan Children.PMID 41898794Read ↗

Gene polymorphisms of TLR10: effects on bacterial meningitis outcomes in Angolan children.Semantic proximity Read ↗

Genetic variations of toll-like receptors: Impact on susceptibility, severity and prognosis of bacterial meningitis.Semantic proximity Read ↗

Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members.Semantic proximity Read ↗

Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children.Semantic proximity Read ↗

Association between TLR2 + 2477G/A polymorphism and bacterial meningitis: a meta-analysis.Semantic proximity Read ↗

Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data.Semantic proximity Read ↗

Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.Semantic proximity Read ↗

Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.Semantic proximity Read ↗

Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort.Semantic proximity Read ↗

Single nucleotide polymorphisms in TLR9 are highly associated with susceptibility to bacterial meningitis in children.Semantic proximity Read ↗

CARD8 polymorphisms among bacterial meningitis patients in North-West EthiopiaSemantic proximity Read ↗

TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.