Article
Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study.
Critical care (London, England) - 1 Jan 2010
Chapman Stephen J, Khor Chiea C, Vannberg Fredrik O, Rautanen Anna, Walley Andrew, Segal Shelley, Moore Catrin E, Davies Robert J O, Day Nicholas P, Peshu Norbert, Crook Derrick W, Berkley James A, Williams Thomas N, Scott J Anthony, Hill Adrian V S
Abstract excerpt
INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points towards a role for genetic variation in the host's immune response. Recent insights from the study of animal models, rare human primary immunodeficiency states,...
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