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Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.

Genes and immunity - 1 Jul 2011

Sanders M S, van Well G T J, Ouburg S, Morré S A, van Furth A M

Abstract excerpt

The susceptibility, severity and prognosis of infectious diseases depend on the ability of the host immune system to respond to pathogens. Genetic variation of immune response genes is associated with susceptibility to and severity of infectious diseases. Bacterial meningitis (BM) is a serious and life-threatening infectious disease of the central nervous system (CNS). Despite adequate antibiotic treatment and...

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Genetic Predisposition to Disease
Genetic Variation
Immunity, Innate
Meningitis, Bacterial
Meningitis, Meningococcal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21471994
DOI: 10.1038/gene.2011.20

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