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Article

A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.

Nature communications - 12 Feb 2016

Hungate Eric A, Vora Sapana R, Gamazon Eric R, Moriyama Takaya, Best Timothy, Hulur Imge, Lee Younghee, Evans Tiffany-Jane, Ellinghaus Eva, Stanulla Martin, Rudant Jéremie, Orsi Laurent, Clavel Jacqueline, Milne Elizabeth, Scott Rodney J, Pui Ching-Hon, Cox Nancy J, Loh Mignon L, Yang Jun J, Skol Andrew D, Onel Kenan

Abstract excerpt

Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility (Pcombined=3.32 × 10(-15), OR=1.72) and independent from rs3731217, the previously...

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Identifiers

PMID: 26868379
DOI: 10.1038/ncomms10635
PMCID: PMC4754340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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