Article
Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia.
Leukemia - 1 Oct 2012
Enciso-Mora V, Hosking F J, Sheridan E, Kinsey S E, Lightfoot T, Roman E, Irving J A E, Tomlinson I P M, Allan J M, Taylor M, Greaves M, Houlston R S
Abstract excerpt
Recent genome-wide association studies (GWAS) have provided the first unambiguous evidence that common genetic variation influences the risk of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), identifying risk single-nucleotide polymorphisms (SNPs) localizing to 7p12.2, 9p21.3, 10q21.2 and 14q11.2. The testing of SNPs individually for an association in GWA studies necessitates the imposition of...
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