Article
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
Nature genetics - 1 Jun 2010
Sherborne Amy L, Hosking Fay J, Prasad Rashmi B, Kumar Rajiv, Koehler Rolf, Vijayakrishnan Jayaram, Papaemmanuil Elli, Bartram Claus R, Stanulla Martin, Schrappe Martin, Gast Andreas, Dobbins Sara E, Ma Yussanne, Sheridan Eamonn, Taylor Malcolm, Kinsey Sally E, Lightfoot Tracey, Roman Eve, Irving Julie A E, Allan James M, Moorman Anthony V, Harrison Christine J, Tomlinson Ian P, Richards Sue, Zimmermann Martin, Szalai Csaba, Semsei Agnes F, Erdelyi Daniel J, Krajinovic Maja, Sinnett Daniel, Healy Jasmine, Gonzalez Neira Anna, Kawamata Norihiko, Ogawa Seishi, Koeffler H Phillip, Hemminki Kari, Greaves Mel, Houlston Richard S
Abstract excerpt
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.
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