Article
Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms.
Diabetes - 1 May 2016
Batchu Sri N, Majumder Syamantak, Bowskill Bridgit B, White Kathryn E, Advani Suzanne L, Brijmohan Angela S, Liu Youan, Thai Kerri, Azizi Paymon M, Lee Warren L, Advani Andrew
Abstract excerpt
Discovery of common pathways that mediate both pancreatic β-cell function and end-organ function offers the opportunity to develop therapies that modulate glucose homeostasis and separately slow the development of diabetes complications. Here, we investigated the in vitro and in vivo effects of pharmacological agonism of the prostaglandin I2 (IP) receptor in pancreatic β-cells and in glomerular podocytes. The IP...
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