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Article

Identification of a receptor for extracellular renalase.

PloS one - 1 Jan 2015

Wang Ling, Velazquez Heino, Chang John, Safirstein Robert, Desir Gary V

Abstract excerpt

BACKGROUND: An increased risk for developing essential hypertension, stroke and diabetes is associated with single nucleotide gene polymorphisms in renalase, a newly described secreted flavoprotein with oxidoreductase activity. Gene deletion causes hypertension, and aggravates acute ischemic kidney (AKI) and cardiac injury. Independent of its intrinsic enzymatic activities, extracellular renalase activates MAPK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25906147
DOI: 10.1371/journal.pone.0122932
PMCID: PMC4407985

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