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Article

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.

The Journal of biological chemistry - 13 Jan 2006

Park Sunmin, Dong Xiaocheng, Fisher Tracy L, Dunn Sarah, Omer A Kadir, Weir Gordon, White Morris F

Abstract excerpt

The insulin receptor substrate 2 (Irs2) branch of the insulin/insulin-like growth factor-signaling cascade prevents diabetes in mice because it promotes beta cell replication, function, and survival, especially during metabolic stress. Because exendin-4 (Ex4), a long acting glucagon-like peptide 1 receptor agonist, has similar effects upon beta cells in rodents and humans, we investigated whether Irs2 signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16272563
DOI: 10.1074/jbc.M508307200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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