Article
Agonists of prostaglandin E 2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies
28 Apr 2022
Abstract excerpt
Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging to the ciliopathy disorders and known as the most common cause of hereditary end-stage renal disease in children. Yet, no curative treatment is available. The major gene, NPHP1, encodes a protein playing key functions at the primary cilium and cellular junctions. Using a medium-throughput drug-screen in NPHP1 knockdown...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.