Article

Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A Pathways

2025-12-08

Abstract excerpt

Harmine and other small molecule inhibitors of the kinase DYRK1A induce human beta cells to replicate and regenerate in vitro and in vivo , and are effective at reversing diabetes in animal models. In addition to its beta cell proliferative and regenerative effects, harmine also induces expression of transcription factors and other genes involved in beta cell differentiation and function, exemplified by PDX1, MA...

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Literature Corpus work: cb976486-5795-5ef4-bd8d-b7fb03af1468
DOI: 10.64898/2025.12.07.692818

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