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Article

Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption.

Scientific reports - 11 Feb 2016

Hirano Mayumi, Hirano Katsuya

Abstract excerpt

The phosphorylation of the 20-kD myosin light chain (MLC) and actin filament formation play a key role in endothelial barrier disruption. MLC is either mono- or di-phosphorylated (pMLC and ppMLC) at T18 or S19. The present study investigated whether there are any distinct roles of pMLC and ppMLC in barrier disruption induced by thrombin. Thrombin induced a modest bi-phasic increase in pMLC and a robust...

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Identifiers

PMID: 26863988
DOI: 10.1038/srep20989
PMCID: PMC4750094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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