Article

MYPT1 is a non-canonical AKAP that tethers PKA to the MLCP signaling node

2023-04-27

Abstract excerpt

The activity of myosin light chain phosphatase (MLCP) is fine-tuned by the phosphorylation status of the MLCP target subunit 1 (MYPT1), which is determined by the antagonistic effects of Rho kinase (ROCK) and cAMP/cGMP-dependent protein kinases (PKA and PKG). PKA is composed of two regulatory (PKA-R, of which four variants exist) and two catalytic (PKAcat) subunits. PKA is targeted to the vicinity of its substrate...

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Literature Corpus work: ae7ac812-608a-5f67-a76e-7b7e5445f945
DOI: 10.1101/2023.04.27.538407

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