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Article

Modulation of HSP27 alters hypoxia-induced endothelial permeability and related signaling pathways.

Journal of cellular physiology - 1 Sept 2009

Liu Tiegang, Guevara Oscar E, Warburton Rod R, Hill Nicholas S, Gaestel Matthias, Kayyali Usamah S

Abstract excerpt

This manuscript describes how the permeability of pulmonary artery microvascular endothelial cell (RPMEC) monolayer is elevated by hypoxia and the role played by HSP27 phosphorylation. p38 MAP kinase activation leading to HSP27 phosphorylation was previously shown by our laboratory to alter the actin cytoskeleton and tethering properties of RPMEC. This effect was independent of hypoxia-induced contractility which...

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Source

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Identifiers

PMID: 19373869
DOI: 10.1002/jcp.21773
PMCID: PMC2891512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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