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Article

Rho and Rac but not Cdc42 regulate endothelial cell permeability

1 Apr 2001

Abstract excerpt

Endothelial permeability induced by thrombin and histamine is accompanied by actin stress fibre assembly and intercellular gap formation. Here, we investigate the roles of the Rho family GTPases Rho1, Rac1 and Cdc42 in regulating endothelial barrier function, and correlate this with their effects on F-actin organization and intercellular junctions. RhoA, Rac1 and Cdc42 proteins were expressed efficiently in human...

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PMID: 11257000
DOI: 10.1242/jcs.114.7.1343

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