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Article

Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier.

American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2010

Zhu Bing, Zhang Li, Creighton Judy, Alexeyev Mikhail, Strada Samuel J, Stevens Troy

Abstract excerpt

Intracellular cAMP is compartmentalized to near membrane domains in endothelium, where it strengthens endothelial cell barrier function. Phosphodiesterase 4D4 (PDE4D4) interacts with the spectrin membrane skeleton and prevents cAMP from accessing microtubules. Expression of a dominant-negative PDE4D4 peptide enables cAMP to access microtubules, where it results in phosphorylation of the nonneuronal...

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Identifiers

PMID: 20639351
DOI: 10.1152/ajplung.00431.2009
PMCID: PMC2957413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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