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Article

Differential regulation of human lung epithelial and endothelial barrier function by thrombin.

American journal of respiratory cell and molecular biology - 1 Nov 2004

Kawkitinarong Kamon, Linz-McGillem Laura, Birukov Konstantin G, Garcia Joe G N

Abstract excerpt

Lung epithelial and endothelial barrier dysfunction is critical to the physiologic derangement observed in acute lung injury, but remains poorly understood. We utilized human alveolar epithelial (A549) and endothelial cells (EC) to study cytoskeletal remodeling, myosin light chain (MLC) phosphorylation and barrier regulation evoked by the edemagenic agent, thrombin. Thrombin-challenged human EC monolayers...

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Identifiers

PMID: 15284075
DOI: 10.1165/rcmb.2003-0432OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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