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Article

eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.

PLoS biology - 1 Apr 2017

García-Ortiz Almudena, Martín-Cofreces Noa B, Ibiza Sales, Ortega Ángel, Izquierdo-Álvarez Alicia, Trullo Antonio, Victor Víctor M, Calvo Enrique, Sot Begoña, Martínez-Ruiz Antonio, Vázquez Jesús, Sánchez-Madrid Francisco, Serrador Juan M

Abstract excerpt

The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-θ (PKC-θ) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28394935
DOI: 10.1371/journal.pbio.2000653
PMCID: PMC5386235

Genes

PFN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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