Article
A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment.
The pharmacogenomics journal - 1 Mar 2017
Park H-W, Tse S, Yang W, Kelly H W, Kaste S C, Pui C-H, Relling M V, Tantisira K G
Abstract excerpt
Treatment with glucocorticoids is associated with lower bone mineral density (BMD). We performed a genome-wide association study to analyze interactive effects between genotypes and cumulative dose of prednisone (PD) over 4.3 years of follow-up period on the final BMD Z-scores in 461 white children from the Childhood Asthma Management Program. No variants met the conventional criteria for genome-wide...
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