Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

doi:10.1056/NEJMoa0911353

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Article

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

The New England journal of medicine - 29 Sept 2011

Tantisira Kelan G, Lasky-Su Jessica, Harada Michishige, Murphy Amy, Litonjua Augusto A, Himes Blanca E, Lange Christoph, Lazarus Ross, Sylvia Jody, Klanderman Barbara, Duan Qing Ling, Qiu Weiliang, Hirota Tomomitsu, Martinez Fernando D, Mauger David, Sorkness Christine, Szefler Stanley, Lazarus Stephen C, Lemanske Robert F, Peters Stephen P, Lima John J, Nakamura Yusuke, Tamari Mayumi, Weiss Scott T

Abstract excerpt

BACKGROUND: The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids. METHODS: We analyzed a small number of statistically powerful variants selected on the basis of a...

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PMID: 21991891
DOI: 10.1056/NEJMoa0911353
PMCID: PMC3667396

Genes

GLCCI1

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