Article
Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children.
PLoS genetics - 1 Dec 2019
Kämpe Anders, Enlund-Cerullo Maria, Valkama Saara, Holmlund-Suila Elisa, Rosendahl Jenni, Hauta-Alus Helena, Pekkinen Minna, Andersson Sture, Mäkitie Outi
Abstract excerpt
Vitamin D is important for normal skeletal homeostasis, especially in growing children. There are no previous genome-wide association (GWA) studies exploring genetic factors that influence vitamin D metabolism in early childhood. We performed a GWA study on serum 25-hydroxyvitamin D (25(OH)D) and response to supplementation in 761 healthy term-born Finnish 24-month-old children, who participated in a randomized...
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