Article

Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

2021-12-03

Abstract excerpt

Understanding the function of non-coding genetic variants represents a formidable challenge for biomedicine. We previously identified genetic variants that influence gene expression only after exposure to a hormone or drug. Using glucocorticoid signaling as a model system, we have now demonstrated, in a genome-wide manner, that exposure to glucocorticoids triggered disease risk variants with previously unclear fun...

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Literature Corpus work: 385cddec-e987-5ed5-b9a7-31038c266f7a
DOI: 10.1101/2021.12.01.470787

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